粒细胞-巨噬细胞集落刺激因子受体β抗体
规格：1mg/1ml
英文名： IL3RB
别名： IL3RB; IL-3RB; IL-3R beta; GM-CSFR Beta; IL 3 receptor beta; IL-5RB; IL-5R beta; IL 5 receptor beta; GM-CSFrβ; GM-CSF receptor beta chain; GM-CSF/IL-3/IL-5 receptor common beta subunit; CSF2RB; IL3RB;
分子量： 97kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GM-CSFR
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse, Bovine,
细胞定位：细胞膜
粒细胞-巨噬细胞集落刺激因子受体β抗体产品介绍：background: GM-CSF Receptor Beta is the v subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Six transcript variants encoding five different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. Function: High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. Subunit: Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. Interacts with TMEM102; this interaction occurs preferentially in the absence of CSF2. Interacts with LYN. Subcellular Location: Membrane; Single-pass type I membrane protein. 粒细胞-巨噬细胞集落刺激因子受体β抗体Tissue Specificity: Defects in CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5) [MIM:614370]. SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Post-translational modifications: May be phosphorylated by LYN. Similarity:粒细胞-巨噬细胞集落刺激因子受体β抗体 Belongs to the type I cytokine receptor family. Type 4 subfamily. Contains 2 fibronectin type-III domains. Gene ID: 1439 Database links: Entrez Gene: 1439 Human Entrez Gene: 12983 Mouse Entrez Gene: 12984 Mouse Omim: 138981 Human SwissProt: P32927 Human SwissProt: P26955 Mouse Unigene: 285401 Human Unigene: 592192 Human Unigene: 235324 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
粒细胞-巨噬细胞集落刺激因子受体β抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid