非受体型酪氨酸蛋白激酶Tnk1抗体
规格：1mg/1ml
英文名： TNK1
别名： CD38 negative kinase 1; EC 2.7.10.2 antibody Kinase of embryonic stem cells; Kos 1; Kos1; MGC46193; Non receptor tyrosine protein kinase TNK 1; Non receptor tyrosine protein kinase TNK1; Tnk 1; Tyrosi
分子量： 73kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TNK1(603
交叉反应：Human, Mouse, Rat, Cow, Horse,
细胞定位：细胞浆 细胞膜
非受体型酪氨酸蛋白激酶Tnk1抗体产品介绍：background: Tnk1 is a nonreceptor protein tyrosine kinase (NRPTK) and a new member of the Ack family of NRPTKs. Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity. Function: Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in ***** tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction非受体型酪氨酸蛋白激酶Tnk1抗体. Subunit: Interacts with the SH3 domain of PLCG1 via its Pro-rich domain. Subcellular Location: Cytoplasm. Membrane; Peripheral membrane protein. Tissue Specificity: Expressed in all umbilical cord blood, bone marrow and ***** blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in ***** prostate, testis, ovary, small intestine and colon. Not expressed in ***** lung, liver, kidney or brain. Post-translational modifications: Autophosphorylated on tyrosine residues. Similarity: 非受体型酪氨酸蛋白激酶Tnk1抗体Belongs to the protein kinase superfamily. Tyr protein kinase family. Contains 1 protein kinase domain. Contains 1 SH3 domain. Gene ID: 8711 Database links: Entrez Gene: 8711 Human Omim: 608076 Human SwissProt: Q13470 Human Unigene: 203420 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
非受体型酪氨酸蛋白激酶Tnk1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid