磷酸化丝裂原活化蛋白激酶激酶8抗体
规格：1mg/1ml
英文名： Phospho-MAP3K8 (Ser400)
别名： MAP3K8 (phospho S400); P-MAP3K8/Tpl2 (Ser400); Phospho-MAP3K8(Ser400); Phospho-Tpl2 (Ser400); P-Tpl2 (Ser400);c COT; Cancer Osaka thyroid oncogene; Cancer Osaka thyroid oncogene; CCOT; COT; COT proto
分子量： 53kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆
磷酸化丝裂原活化蛋白激酶激酶8抗体产品介绍：background: This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011] Function: Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein. Subunit: Forms a ternary磷酸化丝裂原活化蛋白激酶激酶8抗体 complex with NFKB1 and TNIP2. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in several normal tissues and human tumor-derived cell lines. Post-translational modifications: Autophosphorylated. Isoform 1 undergoes phosphorylation mainly on Ser residues, and isoform 2 on both Ser and Thr residues. Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 protein kinase domain. Gene ID: 1326 Database links: Entrez Gene: 1326 Human Entrez Gene:磷酸化丝裂原活化蛋白激酶激酶8抗体 26410 Mouse Entrez Gene: 116596 Rat Omim: 191195 Human SwissProt: P41279 Human SwissProt: Q07174 Mouse SwissProt: Q63562 Rat Unigene: 432453 Human Unigene: 3275 Mouse Unigene: 9939 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化丝裂原活化蛋白激酶激酶8抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid