磷酸化雷帕霉素靶蛋白复合体2抗体
规格：1mg/1ml
英文名： Phospho-Rictor (Thr1135)
别名： Rictor(Phospho-Thr1135); Rictor(Phospho-T1135); p-Rictor(Thr1135); p-Rictor(T1135); AVO3; AVO3 homolog; hAVO3; DKFZp686B11164; hAVO3; KIAA1999; Likely ortholog of mouse TORC2 specific protein AVO3 (S.
分子量： 189kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated Synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Dog, Pig, Cow, Rabbit, Guinea Pig,
细胞定位：
磷酸化雷帕霉素靶蛋白复合体2抗体产品介绍：background: RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]. Function: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of磷酸化雷帕霉素靶蛋白复合体2抗体 SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. Subunit: Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and PRR5 within the TORC2 complex. May interact with PRR5L. Post-translational modifications: Phosphorylated by MTOR; when part of mTORC2磷酸化雷帕霉素靶蛋白复合体2抗体. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling. Similarity: Belongs to the pianissimo family. Gene ID: 253260 Database links: Entrez Gene: 479356 Dog Entrez Gene: 253260 Human Entrez Gene: 78757 Mouse Entrez Gene: 310131 Rat Omim: 609022 Human SwissProt: Q6R327 Human SwissProt: Q6QI06 Mouse Unigene: 407926 Human Unigene: 275811 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化雷帕霉素靶蛋白复合体2抗体产品应用：WB=1:100-1000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid