人类**状瘤病毒33 E6蛋白抗体
规格：1mg/1ml
英文名： HPV33 E6
别名： E6 protein [Human papillomavirus type 33]; Human Papilloma Virus; Human papillomavirus type 33; Human papillomavirus type 33; Protein 33; HPV33-E6 protein; HPV33 E6 protein; VE6_HPV33.
分子量： 16kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HPV33 E6
交叉反应：HPV33
细胞定位：
人类**状瘤病毒33 E6蛋白抗体产品介绍：background: Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro. Human papillomaviruses人类**状瘤病毒33 E6蛋白抗体 (HPV) are small DNA viruses which infect epithelia of the skin and mucosa. Over 90 types have been identified and they mostly cause a variety of benign lesions such as warts and verrucae. However, some subtypes, notably types 人类**状瘤病毒33 E6蛋白抗体16 and 18, 31 and 33, have been confirmed as agents which cause cervical cancer. Function: Transcriptional transactivator. Binds double stranded DNA (By similarity). This protein may be involved in the oncogenic potential of this virus (cervical neoplasia-associated virus) Subcellular Location: Host nucleus matrix (By similarity). Similarity: Belongs to the papillomaviridae E6 protein family. Database links: UniProtKB/Swiss-Prot: P06427.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 人类**状瘤病毒33（HPV33）是导致女性宫颈癌的主要病毒型（包括人类**状瘤病人类**状瘤病毒33 E6蛋白抗体毒33）属于高危亚型人类**状瘤病毒。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 肿瘤细胞生物标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid