肌钙集蛋白/收钙素抗体
规格：1mg/1ml
英文名： Calsequestrin
别名： CASQ; Calsequestrin 1; Calsequestrin 1 fast twitch skeletal muscle; Calsequestrin 2; Calsequestrin 2 fast twitch cardiac muscle; Calsequestrin cardiac muscle isoform; Calsequestrin skeletal muscle iso
分子量： 40kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Calseque
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆 线粒体
肌钙集蛋白/收钙素抗体产品介绍：background: The sarcoplasmic reticulum (SR) is, in part, responsible for maintaining the level of intracellular calcium in cardiac and skeletal muscle by storing and releasing calcium. Several intralumenal SR calcium binding proteins have been identified, the most prominent of these is calsequestrin. Calsequstrin is a calcium binding protein known to sequester calcium accumulated in the sarcoplasmic reticulum of muscle cells during relaxation and is found discretely localized to the junctional and corbular (terminal cisternae) SR. Calsequestrin functions to localize calcium near the junctional face of the terminal cisternae from which calcium can be released into the cytosol via the ryanodine receptor. This protein is highly acidic and has a large capacity and moderate to low affinity for calcium. Function: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin 肌钙集蛋白/收钙素抗体through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+). Subcellular Location: Sarcoplasmic reticulum lumen. Mitochondrion. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Also mitochondrial according to PubMed:7945294. Similarity: Belongs to the calsequestrin family. Gene ID: 844 Database links: Entrez Gene: 844 Human Entrez Gene: 肌钙集蛋白/收钙素抗体12372 Mouse Entrez Gene: 686019 Rat Omim: 114250 Human SwissProt: P31415 Human SwissProt: O09165 Mouse SwissProt: P19633 Rat Unigene: 632476 Human Unigene: 12829 Mouse Unigene: 159963 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 肌钙集蛋白，隐钙素，收钙素，是肌浆网上调控钙储存的主要结合蛋白。CASQ与内质网钙结合蛋白肌钙网蛋白具有同源性（calreticulin）。CASQ1主要在快收缩骨骼肌表达，CASQ2主要在在慢收缩骨骼肌和心肌表达。
肌钙集蛋白/收钙素抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 信号转导 转录调节因子 结合蛋白 线粒体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid