轴突导向因子SEMA6D抗体
规格：1mg/1ml
英文名： SEMA6D
别名： SEM6D_HUMAN; KIAA1479; Q8NFY4; Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D; Semaphorin 6D.
分子量： 118kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SEMA6D
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：
轴突导向因子SEMA6D抗体产品介绍：background: Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct 轴突导向因子SEMA6D抗体encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010] Function: Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Subcellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3:轴突导向因子SEMA6D抗体 Cell membrane; Single-pass type I membrane protein. Isoform 4: Cell membrane; Single-pass type I membrane protein. Isoform 5: Cell membrane; Single-pass type I membrane protein. Isoform 7: Cytoplasm. Similarity: Belongs to the semaphorin family. Contains 1 PSI domain. Contains 1 Sema domain. Gene ID: 80031 Database links: UniProtKB/Swiss-Prot: Q8NFY4.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
轴突导向因子SEMA6D抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 发育生物学 神经生物学 细胞周期蛋白 细胞粘附分子 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid