接头蛋白Gab 2抗体
规格：1mg/1ml
英文名： GAB2
别名： GAB 2; Gab2; Grb 2 associated binder 2; GRB 2 associated binding protein 2; Grb2 associated binder 2; GRB2 associated binder 2 pp100; GRB2 associated binding protein 2; Growth factor receptor bound pr
分子量： 74kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Gab2
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆 细胞膜
接头蛋白Gab 2抗体产品介绍：background: This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009] Function: Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. Subunit: Interacts with SHC1; may mediate interaction with receptors. Interacts with SYK. Interacts with PI-3 kinase. Interacts with GRB2 (via SH3 2 domain). Interacts with PTPN11. Interacts with TNFRSF11A (via cytoplasmic domain). Interacts (phosphorylated) with 14-3-3 family proteins SFN, YWHAB,接头蛋白Gab 2抗体 YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ; prevents interaction with GRB2 and attenuates GAB2 signaling. Subcellular Location: Cytoplasm. Cell membrane Post-translational modifications: Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R. Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANK. Phosphorylated upon EGF stimulation. Dephosphorylated by PTPN11. Similarity: Belongs to the GAB family. Contains 接头蛋白Gab 2抗体1 PH domain. Gene ID: 9846 Database links: Entrez Gene: 9846 Human Entrez Gene: 14389 Mouse Entrez Gene: 84477 Rat Omim: 606203 Human SwissProt: Q9UQC2 Human SwissProt: Q9Z1S8 Mouse SwissProt: Q9EQH1 Rat Unigene: 429434 Human Unigene: 42033 Mouse Unigene: 211990 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
接头蛋白Gab 2抗体产品应用：WB=1:100-500 ELISA=1:2000-5000 IHC-P=1:20-100 IHC-F=1:50-200 Flow-Cyt=1:50-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学 信号转导 细胞膜受体 Alzheimer's
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid