白细胞介白细胞介素27受体抗体素27受体抗体
规格：1mg/1ml
英文名： IL27R
别名： IL-27R; IL27R alpha; Interleukin 27 receptor alpha chain precursor; Interleukin 27; Protein CRL1; Type 1 T cell cytokine receptor; WSX1; Interleukin-27 Receptor, T Cell Cytokine Receptor; IL27R; IL27R
分子量： 70kD
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IL-27R
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
白细胞介白细胞介素27受体抗体素27受体抗体产品介绍：background: Upon antigen challenge, T-helper cells differentiate into two functionally distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-gamma and lymphotoxin-b that augment the cell-mediated immune response, while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned. It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1. TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-gamma and Th1-dependent antibody IgG2a. TCCR is predominantly expressed in thymus, spleen, lymph nodes and peripheral blood leukocytes. Function: Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and白细胞介白细胞介素27受体抗体素27受体抗体 STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and ***** lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level 白细胞介白细胞介素27受体抗体素27受体抗体expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes. Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 3 fibronectin type-III domains. Gene ID: 9466 Database links: Entrez Gene: 9466 Human Entrez Gene: 50931 Mouse Entrez Gene: 288905 Rat Omim: 605350 Human SwissProt: Q6UWB1 Human SwissProt: O70394 Mouse Unigene: 132781 Human Unigene: 38386 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗白细胞介白细胞介素27受体抗体素27受体抗体原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid