轴突生长因子CD108抗体
规格：1mg/1ml
英文名： CD108
别名： semaphorin 7A; CD 108; CD108; CD108 antigen; CDw108; H Sema K1; H Sema L; JMH; JMH blood group antigen; John Milton Hagen blood group H Sema K1; John Milton Hargen human blood group Ag; MGC126692; MGC
分子量： 66kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Sema7A
交叉反应：Human, Mouse, Rat, Dog, Cow,
细胞定位：细胞膜 细胞外基质
轴突生长因子CD108抗体产品介绍：background: Semaphorin 7a is required for central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Semaphorin 7a is also involved in modulating immune function. Semaphorin 7a expression is highest in the brain and increases in late embryonic and postnatal stages. The Semaphorins constitute a large family of secreted and membrane-tethered cell signaling molecules. They have functions in neural development, immunology, cardiac growth, vascular development, lung morphogenesis and axial bone patterning. Semaphorins are defined by the presence of a conserved Sema domain at the N-terminus. These proteins can be classified into eight classes depending on their structure and species origin. Classes 3 through 7 are found in vertebrates; class 3 are secreted, class 7 are GPI-anchored, and class 4 through 6 are transmembrane proteins. Function: Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T cell-mediated immune responses. Promotes axon growth in the embryonic 轴突生长因子CD108抗体olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. Subunit: Interacts with ITGA1 and ITGB1 (Probable). Interacts with PLXNC1. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Note=Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes. Tissue Specificity: Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord,轴突生长因子CD108抗体 lung, heart, adrenal gland, lymph nodes, thymus, intestine and kidney. Similarity: Belongs to the semaphorin family. Gene ID: 8482 Database links: Entrez Gene: 8482 Human Entrez Gene: 20361 Mouse Entrez Gene: 315711 Rat Omim: 607961 Human SwissProt: O75326 Human SwissProt: Q9QUR8 Mouse Unigene: 24640 Human Unigene: 335187 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
轴突生长因子CD108抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 生长因子和** 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid