叉头蛋白M1抗体
规格：1mg/1ml
英文名： FOXM1
别名： FKH L16; FKHL 16; FKHL16; Forkhead box M1; Forkhead box protein M1; Forkhead drosophila homolog like 16; Forkhead Drosophila like 16; Forkhead like 16; Forkhead related protein FKHL16; FOX M1; FOXM 1;
分子量： 84kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FOXM1
交叉反应：Human, Mouse, Rat, Dog, Horse, Rabbit,
细胞定位：细胞核
叉头蛋白M1抗体产品介绍：background: The Forkhead Box (Fox) proteins are an extensive family of transcription factors that share homology in the winged helix DNA-binding domain and the members of which play essential roles in a diverse range of developmental processes as well as cellular proliferation, differentiation, and longevity. The Fox factors are especially important in the establishment of the body axis and the development of tissues from all three germ layers. FOXM1 is also overexpressed in many human cancers and has a role in tumorigenesis. Function: Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response. Subcellular Location: Nucleus. Tissue Specificity: Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in ***** organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is 叉头蛋白M1抗体highly expressed in testis. Post-translational modifications: Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators. Similarity: Contains叉头蛋白M1抗体 1 fork-head DNA-binding domain. Gene ID: 2305 Database links: Entrez Gene: 2305 Human Entrez Gene: 14235 Mouse Entrez Gene: 58921 Rat Omim: 602341 Human SwissProt: Q08050 Human SwissProt: O08696 Mouse SwissProt: P97691 Rat Unigene: 239 Human Unigene: 42148 Mouse Unigene: 10665 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. FOXM1(Forkhead box M1)是Forkhead转录因子家族中的成员，在很多肿瘤组织中都有不同的表达。
叉头蛋白M1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid