白介素21抗体
规格：1mg/1ml
英文名： IL21
别名： IL 21; IL21; IL-21; Interleukin 21; Interleukin21; Za11; IL21_HUMAN; Interleukin-21; interleukin-21 isoform; OTTHUMP00000164088.
分子量： 18kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IL-21
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
细胞定位：分泌型蛋白
白介素21抗体产品介绍：background: This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] Function: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating 白介素21抗体stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Subcellular Location: Secreted. Tissue Specificity: Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. Similarity: Belongs to the IL-15/IL-21 family. Gene ID: 59067 Database links: Entrez Gene: 378475 Cow Entrez Gene: 59067 Human Entrez Gene: 60505 Mouse Omim: 605384 Human SwissProt: Q76LU5 Cow SwissProt: 白介素21抗体Q9HBE4 Human SwissProt: Q9ES17 Mouse Unigene: 567559 Human Unigene: 157689 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 白介素21是多效**调节活性的细胞因子,与其受体结合后可以调节并促进B细胞、T细胞、NK细胞的增殖、分化并提高NK细胞杀伤活性。
白介素21抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid