白细胞介素-12受体β2抗体
规格：1mg/1ml
英文名： IL12RB2
别名： Interleukin-12 receptor subunit beta-2; RP11-102M16.1; IL12 receptor beta 2; IL12R beta2; Interleukin 12 receptor beta 2; Interleukin 12 receptor beta 2 chain; RP11 102M16.1.
分子量： 95kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IL-12RB2
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit,
细胞定位：细胞膜
白细胞介素-12受体β2抗体产品介绍：background: The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. [provided by RefSeq]. Function: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. Subcellular Location: 白细胞介素-12受体β2抗体Membrane; Single pass type I membrane protein. Tissue Specificity: Isoform 2 is expressed at similar levels in both naive and activated T-cells. Post-translational modifications: On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding. Similarity: Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 5 fibronectin type-III domains. Gene ID: 3595 Database links: Entrez Gene: 282452 Cow Entrez Gene: 489550 Dog Entrez Gene: 100722774 Guinea pig Entrez Gene: 3595 Human Entrez Gene: 16162 Mouse Entrez Gene: 397178 Pig Entrez Gene: 100350416 Rabbit Entrez Gene: 白细胞介素-12受体β2抗体171334 Rat Entrez Gene: 100820736 Sheep Omim: 601642 Human SwissProt: Q99665 Human SwissProt: P97378 Mouse Unigene: 479347 Human Unigene: 188337 Mouse Unigene: 207395 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
白细胞介素-12受体β2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid