C型凝集素结构域家族4成员C抗体
规格：1mg/1ml
英文名： CLEC4C
别名： CD303; CLC4C_HUMAN; BDCA-2; CLEC4C; BDCA2; BDCA-2; BDCA 2; Blood dendritic cell antigen 2; Blood dendritic cell antigen 2 protein; C-type (calcium dependent, carbohydrate-recognition domain) lectin, s
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CD303
交叉反应：Human, Mouse,
细胞定位：
C型凝集素结构域家族4成员C抗体产品介绍：background: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. Function: Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activatesC型凝集素结构域家族4成员C抗体 protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose. Subcellular Location: Membrane; Single-pass type II membrane protein (Probable). Tissue Specificity: Expressed in plasmacytoid dendritic cells (PDCs).C型凝集素结构域家族4成员C抗体 Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha. Similarity: Contains 1 C-type lectin domain. Gene ID: 170482 Database links: UniProtKB/Swiss-Prot: Q8WTT0.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
C型凝集素结构域家族4成员C抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 细胞表面分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid