C型凝集素结构域家族6成员A抗体
规格：1mg/1ml
英文名： DECTIN2
别名： DECTIN-2; DECTIN 2; DECTIN2; C type lectin domain family 6 member A; C type lectin superfamily member 10; C-type lectin domain family 6 member A; C-type lectin superfamily member 10; CLC6A_HUMAN; CLEC
分子量： 24kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Dectin-2
交叉反应：Human, Mouse, Rat, Cow, Horse, Sheep,
细胞定位：
C型凝集素结构域家族6成员A抗体产品介绍：background: Dectin 2 is a type II transmembrane protein that is a member of the C type lectin superfamily. In mouse, dectin 2 is predominantly expressed on tissue macrophages and some dendritic cells. Significant expression of Dectin 2 has been reported on macrophages in the red pulp and marginal zones of the spleen, kupffer cells in the liver and alveolar macrophages in the lung. Peripheral blood monocytes express low levels of dectin 2 but transient up regulation of expression has been demonstrated on monocytes at sites of inflammation. The function of dectin 2 has not been fully determined but studies suggest a possible role in immune surveillance. Function: Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas.C型凝集素结构域家族6成员A抗体 Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptative immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway (By similarity). Subunit: Associated with FCER1G. Subcellular Location: Membrane; Single-pass type II membrane protein (Probable). Tissue Specificity: Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic C型凝集素结构域家族6成员A抗体cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids. Similarity: Contains 1 C-type lectin domain. Gene ID: 93978 Database links: Entrez Gene: 93978 Human Entrez Gene: 56620 Mouse Omim: 613579 Human SwissProt: Q6EIG7 Human SwissProt: Q9JKF4 Mouse SwissProt: D3ZWT9 Rat Unigene: 591147 Human Unigene: 271782 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
C型凝集素结构域家族6成员A抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid