C型凝集素结构域家族1成员B抗体
规格：1mg/1ml
英文名： CLEC2
别名： C-type lectin domain family 1 member B; 1810061I13Rik; C type lectin domain family 1 member B; C type lectin like receptor 2; C-type lectin domain family 1, member B; C-type lectin-like receptor-2; CL
分子量： 27kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CLEC2
交叉反应：Human, Mouse, Rat, Cow,
细胞定位：细胞膜
C型凝集素结构域家族1成员B抗体产品介绍：background: Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011] Function: Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency C型凝集素结构域家族1成员B抗体virus type 1 (HIV-1) and facilitates its capture by platelets. Subunit: Homodimer. Subcellular Location: Membrane; Single-pass type II membrane protein (Probable). Tissue Specificity: Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets. Post-translational modifications: Glycosylated. Phosphorylated on tyrosine residue in response to rhodocytin bindingC型凝集素结构域家族1成员B抗体. Similarity: Contains 1 C-type lectin domain. Gene ID: 51266 Database links: Entrez Gene: 51266 Human Omim: 606783 Human SwissProt: Q9P126 Human Unigene: 221418 Human Unigene: 409794 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
C型凝集素结构域家族1成员B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid