干扰素调节因子4抗体
规格：1mg/1ml
英文名： IRF4
别名： Interferon regulatory factor 4; IRF 4; IRF4; IRF-4; LSIRF; Lymphocyte specific interferon regulatory factor; Multiple myeloma oncogene 1; MUM 1; NF EM5; NFEM5; OTTHUMP00000017905; PU.1 interaction par
分子量： 52kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IRF-4
交叉反应：Human, Mouse, Rat, Chicken, Cow, Horse,
细胞定位：细胞核
干扰素调节因子4抗体产品介绍：background: The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010] Function: Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity). Subunit: Interacts with the BATF-JUNB heterodimer. 干扰素调节因子4抗体Interacts with BATF (via bZIP domain); the interaction is direct. Interacts with SPIB and DEF6. Subcellular Location: Nucleus. Tissue Specificity: Lymphoid cells. Post-translational modifications: Phosphorylation by ROCK2 regulates IL-17 and IL-21 production. DISEASE: Multiple myeloma (MM) [MIM:254500]: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving IRF4 has been found in multiple myeloma. Translocation t(6;14)(p25;q32) with the IgH locus. Similarity: Belongs to the IRF family.干扰素调节因子4抗体 Contains 1 IRF tryptophan pentad repeat DNA-binding domain. Gene ID: 3662 Database links: Entrez Gene: 374179 Chicken Entrez Gene: 3662 Human Entrez Gene: 16364 Mouse Entrez Gene: 291100 Rat Omim: 601900 Human SwissProt: Q15306 Human SwissProt: Q64287 Mouse Unigene: 401013 Human Unigene: 4677 Mouse Unigene: 82114 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 转录调节因子（Transcriptin Regulators） 干扰素调节因子家族是一大类对干扰素起调控作用的转录因子的统称。一般认为干扰素调节因子(IRF)通过调节干扰素的表达干扰素调节因子4抗体而行使其抗病毒、应激、**调节功能。近年来，研究人员发现IRF在细胞凋亡、细胞周期、细胞分化、肿瘤发生中也起着重要的调节作用。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid