β葡聚糖受体抗体
规格：1mg/1ml
英文名： beta Glucan Receptor
别名： Dectin1; Dectin-1; Dectin 1; CLECSF12; C-type lectin domain family 7 member A; beta Glucan Receptor; Beta GR; BGR; C type calcium dependent carbohydrate recognition domain lectin superfamily member 12
分子量： 28kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Dectin-1
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
β葡聚糖受体抗体产品介绍：background: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq]. Function: Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates productionβ葡聚糖受体抗体 of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity). Subunit: Homodimer. Interacts with SYK; participates in leukocyte activation in presence of fungal pathogens. Subcellular Location: Cell membrane; Single-pass type II membrane protein. Tissueβ葡聚糖受体抗体 Specificity: Detected in dendritic cells, in paracortical and medullary regions of lymph nodes, and in spleen red pulp and white pulp. Post-translational modifications: on tyrosine residues in response to glucan binding. Similarity: Contains 1 C-type lectin domain. Gene ID: 64581 Database links: Entrez Gene: 64581 Human Entrez Gene: 56644 Mouse Entrez Gene: 502902 Rat Omim: 606264 Human SwissProt: Q9BXN2 Human SwissProt: Q6QLQ4 Mouse Unigene: 143929 Human Unigene: 239516 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. β-葡聚糖受体是一种非调理素依赖性受体,可在**反应早期,在**衰老细胞和防御感染方面发挥重要作用,进而实现其抗肿瘤、抗感染等生物学效应。
β葡聚糖受体抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 **细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid