锚定蛋白G抗体
规格：1mg/1ml
英文名： Ankyrin G
别名： ANK-3; ANK-3; ANK3; ANK3_HUMAN; ankyrin 3 (G); Ankyrin 3, node of Ranvier (ankyrin G); Ankyrin 3, node of Ranvier; Ankyrin G119; Ankyrin-3; Ankyrin-G; brain specific ankyrin G; CHANK3.
分子量： 481/220kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Ankyrin
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆
锚定蛋白G抗体产品介绍：background: human: Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Alternatively spliced variants may be expressed in other tissues. Although multiple transcript variants encoding several different isoforms have been found for this gene, the full-length nature of only two have been characterized. [provided by RefSeq] mouse: This gene encodes a member of the ankyrin protein family. Ankyrins link integral membrane proteins to the spectrin-based Ankyrins link integral membrane proteins to the spectrin-based cytoskeleton. Ankyrin family members share a protein structure which includes three independently folded domains: the N-terminal ankyrin repeat domain, the central spectrin-binding domain, and the C-terminal rod domain. This ankyrin functions as the major ankyrin in the kidney and may play a role in the polarized distribution of many integral membrane proteins to specific subcellular sites. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms锚定蛋白G抗体. Function: In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Subunit: Directly interacts with DMD and betaDAG1. This interaction does not interfere with binding between DMD and betaDAG1. It is also required for DMD and betaDAG1 retention at costameres (By similarity). Interacts (via N-terminal ANK repeats) with SCHIP1 isoform 5 (via C-terminus); this interaction is required for the localization at axon initial segments (AISs) and nodes of Ranvier (NRs) (By similarity). May be a constituent of a neurofascin/NRCAM/ankyrin G complex. Interacts with RHBG. Subcellular Location: Cytoplasm, cytoskeleton. Cell junction, synapse, postsynaptic cell membrane (By similarity). 锚定蛋白G抗体Lysosome (By similarity). Note=In skeletal muscle, localized at costameres and neuromuscular junctions (By similarity). In macrophages, associated with lysosomes (By similarity). Tissue Specificity: Expressed in brain, neurons and other tissues. DISEASE: Note=Genetic variations in ANK3 are associated with autism spectrum disorders susceptibility. Similarity: Contains 23 ANK repeats. Contains 1 death domain. Contains 2 ZU5 domains. Gene ID: 288 Database links: Entrez Gene: 288 Human Entrez Gene: 11735 Mouse Entrez Gene: 361833 Rat Omim: 600465 Human SwissProt: Q12955 Human SwissProt: G5E8K5 Mouse SwissProt: Q4U206 Mouse Unigene: 499725 Human Unigene: 235960 Mouse Unigene: 202383 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 锚定蛋白G是一个分子量在480KDa大分子细胞内蛋白。 锚蛋白(ankyrin)锚蛋白属于联结蛋白家族,广泛存在于各种组织细胞中。锚蛋白连接整合膜蛋白到细胞骨架蛋白网络,在多种细胞功能活动中起关键作用,参与机体生长、发育、细胞内锚定蛋白G抗体蛋白转运、细胞极性的建立和维持、细胞黏附、信号传导以及mRNA转录等。
产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 信号转导 细胞粘附分子 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid