脑衰蛋白反应调节蛋白4抗体
规格：1mg/1ml
英文名： CRMP4
别名： Unc 33 like phosphoprotein; Collapsin response mediator protein 4; Collapsin response mediator protein 4 long; CRMP 4; CRMP4; Dihydropyrimidinase like 3; Dihydropyrimidinase related protein 3; DPYSL3;
分子量： 62kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CRMP4
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse,
细胞定位：细胞浆
脑衰蛋白反应调节蛋白4抗体产品介绍：background: The collapsin response mediator protein (CRMP) family of five cytosolic phosphoproteins are highly expressed throughout brain development. The functions of CRMPs encompass signal transduction in developmental guidance cues as well as multiple cellular and molecular events involved in apoptosis/proliferation, cell migration, and differentiation. In the ***** brain, the expression of CRMPs is dramatically downregulated. However, CRMPs remain expressed in structures that retain their capacity for differentiation and plasticity. The expression of CRMPs is altered in neurodegenerative diseases, and these proteins may have a role in the physiopathology of the ***** nervous system. Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). Subunit: Homotetramer, and heterotetramer with CRMP1,脑衰蛋白反应调节蛋白4抗体 DPYSL2, DPYSL4 or DPYSL5 (By similarity). Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin (By similarity). Subcellular Location: Cytoplasmic. Cell projection, growth cone (By similarity). Note: Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone. Post-translational modifications: Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3. Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. Gene ID: 1809 Database脑衰蛋白反应调节蛋白4抗体 links: Entrez Gene: 1809 Human Entrez Gene: 22240 Mouse Entrez Gene: 25418 Rat Omim: 601168 Human SwissProt: Q14195 Human SwissProt: Q62188 Mouse SwissProt: Q62952 Rat Unigene: 519659 Human Unigene: 428551 Mouse Unigene: 8180 Mouse Unigene: 93365 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
脑衰蛋白反应调节蛋白4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid