FCRLM1蛋白抗体
规格：1mg/1ml
英文名： FCRLM1
别名： Fc receptor homolog expressed in B cells; Fc receptor like A; Fc receptor like and mucin like 1; Fc receptor like and mucin like protein 1; Fc receptor like protein; Fc receptor related protein X; FCR
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FCRLM1
交叉反应：Human, Mouse, Rat, Cow, Sheep,
细胞定位：细胞浆 分泌型蛋白
FCRLM1蛋白抗体产品介绍：background: This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011] Function: FCRLM1 belongs to a family of receptors for the Fc fragment of IgG, or FCGRs which are cell surface glycoproteins of the Ig superfamily (IgSF). These receptors mediate phagocytosis of IgG-coated pathogens and promote activation of effector cells, leading to inflammatory responses and antibody-mediated cellular cytotoxicity. FCRLM1 may be involved in B-cell differentiation and lymphomagenesis. Subunit: Monomer FCRLM1蛋白抗体or homodimer; disulfide-linked. Subcellular Location: Secreted. Cytoplasm. Tissue Specificity: Expressed specifically in primary and secondary lymphoid tissues like lymph node, spleen and tonsil. Specifically expressed in B-cells with a high level in normal germinal center B-cells, FCRLM1蛋白抗体centroblasts and in a subset of diffuse large B-cell lymphomas. Highly expressed in bone marrow B-cells and weakly in earlier B lineage cells. Expressed in pre-germinal and germinal center B-cells in secondary lymphoid tissues. Also expressed in melanoma and melanocytes. Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Gene ID: 84824 Database links: Entrez Gene: 84824 Human Omim: 606891 Human SwissProt: Q7L513 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
FCRLM1蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid