少突胶质细胞跨膜蛋白抗体
规格：1mg/1ml
英文名： Claudin 11/Oligodendrocyte Specific Protein
别名： Oligodendrocyte Specific Protein; Oligodendrocyte transmembrane protein; Claudin 11; claudin11; claudin-11; CLDN 11; CLDN11; Oligodendrocyte transmembrane protein; OSP; OTM.
分子量： 22kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Claudin-
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
细胞定位：细胞膜
少突胶质细胞跨膜蛋白抗体产品介绍：background: Oligodendrocyte specific protein (OSP)is the third most abundant component of central nervous system myelin. The claudin superfamily consists of many structurally related proteins. These proteins, which include claudin 1 through 18, are located in both epithelial and endothelial cells in all tight junction bearing tissues. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. There is growing evidence that OSP/Claudin 11 determines the permeability between layers of myelin sheaths via focal adhesion. Its expression is highly regulated during development, suggesting that it may play an important 少突胶质细胞跨膜蛋白抗体role in the growth and differentiation of oligodendrocytes and other cells outside the CNS. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease. Subunit: Interacts with tetraspanin-3/TSPAN3. Subcellular Location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the claudin family. Gene ID: 5010 Database 少突胶质细胞跨膜蛋白抗体links: Entrez Gene: 508268. Cow Entrez Gene: 5010 Human Entrez Gene: 18417 Mouse Entrez Gene: 84588 Rat Omim: 601326 Human SwissProt: Q3MHK4 Cow SwissProt: O75508 Human SwissProt: Q60771 Mouse SwissProt: Q99P82 Rat Unigene: 31595 Human Unigene: 4425 Mouse Unigene: 8282 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
少突胶质细胞跨膜蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 信号转导 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid