乙型肝炎病毒X蛋白上调基因4
规格：1mg/1ml
英文名： URG4
别名： FLJ20654; HBV X protein up-regulated gene 4 protein; HBV X protein upregulated gene 4 protein; HBxAg up-regulated gene 4 protein; HBxAg upregulated gene 4 protein; KIAA1507; Up-regulator of cell proli
分子量： 105kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human URG4
交叉反应：Human, Mouse, Rat,
细胞定位：
乙型肝炎病毒X蛋白上调基因4产品介绍：background: URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002 [PubMed 12082552]).[supplied by OMIM, Mar 2008] Function: May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer. Subcellular Location: Cytoplasm. Nucleus. Note=In epithelial cells localized predominantly乙型肝炎病毒X蛋白上调基因4 in the cytoplasm and occasionally in nuclei. Tissue Specificity: Strongly expressed in hepatitis B virus-infected liver and in HCC cells. Also highly expressed in well-differentiated gastric cancer tissues and various gastric cancer cell lines. Gene ID: 55665 Database links: Entrez Gene: 55665 Human Omim: 610337 Human SwissProt: Q8TCY9 Human Unigene: 709317 Human Important Note: This product as supplied is 乙型肝炎病毒X蛋白上调基因4intended for research use only, not for use in human, therapeutic or diagnostic applications. HBx是HBV感染、复制、发病和可能致癌关键蛋白,是具有多种功能的病毒调节因子,在慢性HBV感染的病程中占有举足轻重的作用 。URG4(Upregulated gene 4)也是一个从肝癌细胞中克隆出来的可以被HBx蛋白上调的新分子，URG4过量表达在乙型肝炎感染和肝癌细胞中。
乙型肝炎病毒X蛋白上调基因4产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 细胞周期蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid