抑癌蛋白DKK1抗体
规格：1mg/1ml
英文名： DKK1
别名： Dickkopf 1; Dickkopf 1 like; Dickkopf homolog 1; Dickkopf related protein 1; DKK 1; hDkk 1; hDkk1; DKK-1; SK.
分子量： 29kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DKK1
交叉反应：Human, Mouse, Rat,
细胞定位：分泌型蛋白
抑癌蛋白DKK1抗体产品介绍：background: This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008] Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by抑癌蛋白DKK1抗体 forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the *****, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Subcellular Location: Secreted. Tissue Specificity: Placenta. Similarity: Belongs to the dickkopf family. Gene ID: 22943 Database links: Entrez Gene: 22943 Human抑癌蛋白DKK1抗体 Entrez Gene: 13380 Mouse Entrez Gene: 293897 Rat Omim: 605189 Human SwissProt: O94907 Human SwissProt: O54908 Mouse Unigene: 40499 Human Unigene: 214717 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. DKK1是一种分泌蛋白，也是Wnt信号途径的一个抑制蛋白，在多种恶性肿瘤细胞系中高度表达，在肿瘤的发生、发展中有重要作用.
抑癌蛋白DKK1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 信号转导 细胞凋亡 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid