肿瘤坏死因子α诱导蛋白1抗体
规格：1mg/1ml
英文名： TNFAIP1
别名： tumor necrosis factor, alpha-induced protein 1-like; Tumor necrosis factor-alpha-induced protein 1; Tumor necrosis factor alpha induced protein 1 (endothelial); BACD2_HUMAN; BTB/POZ domain-containing
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TNFAIP1
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核 细胞浆
肿瘤坏死因子α诱导蛋白1抗体产品介绍：background: This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]. Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. Subcellular Location:肿瘤坏死因子α诱导蛋白1抗体 Cytoplasm. Nucleus. Endosome. Colocalizes with RHOB in endosomes. Post-translational modifications: Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA. Similarity: Belongs to the BACURD family. Contains 1 BTB (POZ) domain. Gene ID: 7126 Database links: Entrez Gene: 7126 Human Entrez Gene: 21927 Mouse Entrez Gene: 287543 Rat Omim: 191161肿瘤坏死因子α诱导蛋白1抗体 Human SwissProt: Q13829 Human SwissProt: O70479 Mouse SwissProt: Q7TNY1 Rat Unigene: 76090 Human Unigene: 386774 Mouse Unigene: 18199 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. TNFAIP1 protein是**个被鉴定受肿瘤坏死因子α诱导的蛋白,实验证明TNFAIP1 蛋白可能参与DNA复制、合成、细胞凋亡以及人类的各种**等重要生理过程，但还有一些功能不清。
肿瘤坏死因子α诱导蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid