溶质载体家族蛋白9成员3调节因子2抗体
规格：1mg/1ml
英文名： SLC9A3R2
别名： E3KARP; HGNC:11076; Isoform 3 regulator 2; Isoform 3 regulatory factor 2; MGC104639; Na(+)/H(+) exchange regulatory cofactor NHE RF2; Na(+)/H(+) exchange regulatory cofactor NHE-RF2; NHE3 kinase A reg
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SLC9A3R2
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：细胞核
溶质载体家族蛋白9成员3调节因子2抗体产品介绍：background: This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] Function: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton 溶质载体家族蛋白9成员3调节因子2抗体and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus. Subcellular Location: Endomembrane system. Nucleus. Apical cell membrane. Localizes with EZR and PODXL at the apical cell membrane of glomerular epithelium cells and the sides of the food processes (By similarity). Nuclear, in a punctate pattern. Tissue Specificity: Widely expressed. Similarity: Contains 2 PDZ (DHR) domains. Database links: Entrez Gene: 768005 Cow Entrez 溶质载体家族蛋白9成员3调节因子2抗体Gene: 9351 Human Entrez Gene: 65962 Mouse Entrez Gene: 100008813 Rabbit Entrez Gene: 116501 Rat Omim: 606553 Human SwissProt: Q15599 Human SwissProt: Q9JHL1 Mouse SwissProt: Q8SQG9 Rabbit SwissProt: Q920G2 Rat Unigene: 440896 Human Unigene: 21587 Mouse Unigene: 39351 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
溶质载体家族蛋白9成员3调节因子2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 **学 信号转导 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid