碳酸氢钠协同转运蛋白4-A8抗体
规格：1mg/1ml
英文名： SLC4A8
别名： Electroneutral Na(+)-driven Cl-HCO3 exchanger; Electroneutral sodium bicarbonate exchanger 1; k-NBC3; S4A8_HUMAN; Slc4a8; SLC4A8 protein; Solute carrier family 4 member 8.
分子量： 117kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SLC4A8
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
碳酸氢钠协同转运蛋白4-A8抗体产品介绍：background: The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] Function: Mediates electroneutral sodium- and carbonate-dependent choride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. Subcellular Location: Membrane.碳酸氢钠协同转运蛋白4-A8抗体 Tissue Specificity: Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex. Similarity: Belongs to the anion exchanger (TC 2.A.31) family. Database links: Entrez Gene: 9498 Human Entrez Gene: 59033 Mouse Entrez Gene: 315311 Rat Omim: 605024 Human SwissProt: Q2Y0W8 Human SwissProt: Q8TC60 Human SwissProt: Q8JZR6 Mouse碳酸氢钠协同转运蛋白4-A8抗体 SwissProt: Q6RVG2 Rat Unigene: 370636 Human Unigene: 209856 Mouse Unigene: 210164 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
碳酸氢钠协同转运蛋白4-A8抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 新陈代谢
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid