整合素β5抗体
规格：1mg/1ml
英文名： Integrin beta 5
别名： Integrin beta 5; Integrin beta-5; integrin, beta 5; ITB5_HUMAN; Itgb5; AA475909; AI874634; beta-5; beta5; ESTM23; [b]-5; [b]5; [b]5A; [b]5B) FLJ26658; ITGB 5; ITGB5;
分子量： 86kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Integrin
交叉反应：Human, Mouse, Rat, Pig, Cow,
细胞定位：
整合素β5抗体产品介绍：background: Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around 22 different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N terminal extracellular domain that binds the ECM ligand and a small C terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function. The integrin subunit beta 5 has only been associated with the alpha v subunit to form the alpha v beta 5 heterodimer. This integrin mediates cell整合素β5抗体 adhesion to vitronectin and also recognizes fibronectin when the integrin is activated. This integrin is found in a variety of cells in most normal tissue. Function: Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. Subunit: Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V. Interacts with MYO10. Interacts with DAB2. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Belongs to the integrin beta chain family. Contains 1 PSI domain. Contains 1 VWFA domain. Gene ID: 3693 Database 整合素β5抗体links: Entrez Gene: 3693 Human Entrez Gene: 16419 Mouse Entrez Gene: 257645 Rat Omim: 147561 Human SwissProt: P18084 Human SwissProt: O70309 Mouse Unigene: 536663 Human Unigene: 6424 Mouse Unigene: 16988 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
整合素β5抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid