肿瘤坏死因子配体超家族成员10C
规格：1mg/1ml
英文名： DcR1
别名： Decoy receptor 1;TNFRSF10C; CD263; DcR 1; LIT; Lymphocyte inhibitor of TRAIL; TNF Related Apoptosis Inducing Ligand Receptor 3; TNFRSF10C; TRAIL R3; TRAIL receptor 3; TRAIL Receptor Without An Intrace
分子量： 23kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TNFRSF10
交叉反应：Human,
细胞定位：细胞膜
肿瘤坏死因子配体超家族成员10C产品介绍：background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.肿瘤坏死因子配体超家族成员10C [provided by RefSeq, Jul 2008]. Function: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart. Post-translational modifications: N-glycosylated and O-glycosylated. Similarity: Contains 3 TNFR-Cys repeats. Gene ID: 8794 Database links: Entrez Gene: 8794 Human Omim: 603613 Human肿瘤坏死因子配体超家族成员10C SwissProt: O14798 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. DcR1因缺乏细胞内信号传导系统而不能传递凋亡信号,但能竞争性与TRAIL（肿瘤坏死因子相关凋亡诱导配体）结合,有干扰凋亡信号的传导作用。
肿瘤坏死因子配体超家族成员10C产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 细胞凋亡 转录调节因子 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid