CD44V6抗体
规格：1mg/1ml
英文名： CD44V6/HCAM
别名： Homing Cell Adhesion Molecule; Epican; Heparan sulfate proteoglycan; Hyaluronate receptor; Antigen gp90 homing receptor; CD44; CD44 antigen; CD44 antigen homing function and Indian blood group system;
分子量： 53kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from rat CD44V6/HCA
交叉反应：Mouse, Rat,
细胞定位：细胞膜
CD44V6抗体产品介绍：background: CD44 is the receptor for hyaluronic acid (HA). It mediates cell to cell and cell matrix interactions through its affinity for HA. Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. High protein heterogeneity due to several alternative splicing and post translational modification events. CD44R represents a heterogeneous group of CD44 variant isoforms expressed constitutively in epithelial cells and monocyte lineage cells and can be upregulated in activated leukocytes. CD44R, and in particular CD44v6 containing isoforms, may be involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to sites of inflammation. CD44v6 containing isoforms may be involved in tumor metastasis. The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. CD44V6抗体Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq]. Function: Main cell surface receptor for hyaluronate. Adhesion to ucosal high endothelial venule and to types I and VI collagen. robably involved in matrix adhesion, lymphocyte activation and ymph node homing. Subunit: Interacts with PKN2. Subcellular Location: Membrane; Single-pass type I membrane protein. Note=Colocalizes with actin in membrane protrusions at wounding edges. Post-translational modifications: N-glycosylated. O-glycosylated; contains chondroitin sulfate glycans which an be more or less sulfated. Phosphorylated; activation of PKC results in the ephosphorylation of Ser-467 (constitutive phosphorylation site), nd the phosphorylation of Ser-433. Similarity: Contains 1 Link domain. GeneCD44V6抗体 ID: 25406 Database links: Entrez Gene: 960 Human Entrez Gene: 12505 Mouse Entrez Gene: 25406 Rat Omim: 107269 Human SwissProt: P16070 Human SwissProt: P15379 Mouse SwissProt: P26051 Rat Unigene: 502328 Human Unigene: 423621 Mouse Unigene: 1120 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD44V6参与细胞与细胞、细胞与基质问的黏附,与细胞骨架蛋白结合，并与细胞的迁移运动有关,与肿瘤细胞的浸润与转移有关。
CD44V6抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid