血型糖蛋白A + B/涎糖蛋白A + B抗体
规格：1mg/1ml
英文名： Glycophorin A + B
别名： Glycophorin A; AI853584; CD235a; GPA; Blood group-MN locus; CD235a antigen; Glycophorin A (MNS blood group); Glycophorin A includes MN blood group; Glycophorin A precursor; Glycophorin A, included; Gl
分子量： 14/8kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Glycopho
交叉反应：Human,
细胞定位：
血型糖蛋白A + B/涎糖蛋白A + B抗体产品介绍：background: Glycophorins A, B and C are sialoglycoproteins of the human erythrocyte membrane, which bear the antigenic determinants for the MN, Ss and Gerbich blood groups, respectively. Glycophorins span the membrane once and present their amino-terminal end to the extracellular surface of the human erythrocyte. The genetic array of expressed glycophorin surface antigens on erythrocytes defines the blood group phenotype of the individual. The human Glycophorin A gene maps to chromosome 4q31.21, contains seven exons which are 97% homologous to Glycophorin B, and encodes a 150 amino acid protein. The human Glycophorin B gene maps to chromosome 4q31.21 and encodes a 91 amino acid protein. The human Glycophorin C gene maps to chromosome 2q14.3 and contains four exons. Glycophorin C transcript can generate two protein isoforms. Isoform 1 includes all 4 exons and encodes the full length 128 amino acid protein. Isoform 2 is missing exon 2 and encodes a 109 amino acid protein, which specifies the Yus subtype of the Gerbich phenotype. Function: Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane,血型糖蛋白A + B/涎糖蛋白A + B抗体 has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV). Subunit: Homodimer. Interacts with Streptococcus gordonii has protein. Subcellular Location: Cell membrane; 血型糖蛋白A + B/涎糖蛋白A + B抗体Single-pass type I membrane protein. Note=Appears to be colocalized with SLC4A1. Post-translational modifications: The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues. Similarity: Belongs to the glycophorin A family. Gene ID: 2993 Database links: Entrez Gene: 2993 Human Entrez Gene: 2994 Human SwissProt: P02724 Human SwissProt: P06028 Human Unigene: 434973 Human Unigene: 654368 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
血型糖蛋白A + B/涎糖蛋白A + B抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid