GATA2/GATA3抗体
规格：1mg/1ml
英文名： GATA2 + GATA3
别名： DCML; Endothelial transcription factor GATA 2; Endothelial transcription factor GATA-2; Endothelial transcription factor GATA2; FLJ45948; GATA 2; GATA binding factor 3; GATA binding protein 2; GATA bi
分子量： 53kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GATA2 +
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
GATA2/GATA3抗体产品介绍：background: Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as in erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. Both GATA-4 and GATA-6 are found in heart, pancreas and ovary; lung and liver tissues exhibit GATA-6, but not GATA-4 expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expressionGATA2/GATA3抗体 patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites. Function: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Subcellular Location: Nucleus. Tissue Specificity: Endothelial cells. DISEASE: Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome. Similarity: Contains 2 GATA-type zinc fingers. Gene ID: 2624 2625 Database links: Entrez Gene: 2624 Human Entrez Gene: 2625 Human Entrez Gene: 14461 Mouse Entrez Gene: 14462 Mouse Entrez Gene: 25159 Rat Entrez Gene: 85471 Rat Omim: 131320 Human Omim: 137295 Human SwissProt: P23769 HumanGATA2/GATA3抗体 SwissProt: P23771 Human SwissProt: O09100 Mouse SwissProt: P23772 Mouse SwissProt: Q924Y4 Rat Unigene: 367725 Human Unigene: 524134 Human Unigene: 313866 Mouse Unigene: 34322 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
GATA2/GATA3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 信号转导 干细胞 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid