锚蛋白重复域54抗体
规格：1mg/1ml
英文名： ANKRD54
别名： Ankrd54; ankyrin repeat domain 54; ankyrin repeat domain 54; Ankyrin repeat domain-containing protein 54; ANR54_HUMAN; LIAR.
分子量： 32kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ANKRD54
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核 细胞浆
锚蛋白重复域54抗体产品介绍：background: ANKRD54 is a 300 amino acid protein that contains four ankyrin repeats and is expressed as two alternatively spliced isoforms. The gene encoding human ANKRD54 maps to chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias. Function: Plays an important role in regulating intracellular signaling events associated with 锚蛋白重复域54抗体erythroid terminal differentiation. Subunit: Interacts (via ankyrin repeat region) with LYN (via SH3-domain) in an activation-independent status of LYN (By similarity). Forms a multiprotein complex with LYN and HCLS1. Interacts with TSN2, VAV1, DBNL AND LASP1. Subcellular Location: Nucleus. Cytoplasm. Midbody. Note=Shuttles between nucleus and cytoplasm during the cell cycle. EPO stimulation induces nuclear accumulation. Similarity: Contains 4 ANK repeats. Gene ID: 129138 Database links: Entrez Gene: 129138 Human Entrez Gene: 223690锚蛋白重复域54抗体 Mouse Entrez Gene: 362957 Rat Omim: 613383 Human SwissProt: Q6NXT1 Human SwissProt: Q91WK7 Mouse SwissProt: Q566C8 Rat Unigene: 135259 Human Unigene: 24262 Mous Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
锚蛋白重复域54抗体研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid