E3连接酶抑制素受体2抗体
规格：1mg/1ml
英文名： HECTD2
别名： FLJ16050; FLJ37306; HECD2_HUMAN; HECT domain containing 2; HECT domain containing protein 2; HECT domain-containing protein 2; Hectd2; OTTHUMP00000020086; OTTHUMP00000038605; Probable E3 ubiquitin pro
分子量： 88kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HECTD2
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核 细胞浆
E3连接酶抑制素受体2抗体产品介绍：background: HECT (Homologous to the E6-AP Carboxyl Terminus) proteins are a large group of E3 ubiquitin-ligases that play a role in the specificity and selectivity of ubiquitylation. The human genome encodes at least 20 different HECT domain proteins, which are grouped into two classes based on their E2 specificity. HECT enzymes also regulate the trafficking of many receptors, transporters, viral proteins and channels. Since HECT proteins are involved in the degradation of vital tumor suppressor molecules, it is theorized that some may contribute to tumorigenesis. HECTD2 (HECT domain-containing protein 2) is a 776 amino acid E3 ubiquitin-ligase that characteristically accepts ubiquitin from an E2 ubquitin-conjugating enzyme and directly transfers the ubiquitin to targeted substrates. Recently,E3连接酶抑制素受体2抗体 HECTD2 haplotypes have been linked to the susceptibility of acquiring human prion diseases such as Creutzfeldt-Jakob Disease and kuru, which present after a long, clinically silent incubation period that seems to be determined by factors such as genetic background. Function: Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. Gene ID: 143279E3连接酶抑制素受体2抗体 Database links: Entrez Gene: 143279 Human Entrez Gene: 226098 Mouse Entrez Gene: 100172010 Orangutan Entrez Gene: 309514 Rat SwissProt: Q5U5R9 Human SwissProt: Q8CDU6 Mouse SwissProt: Q5RD78 Orangutan Unigene: 596096 Human Unigene: 61107 Mouse Unigene: 24395 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
E3连接酶抑制素受体2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid