透明质酸介导细胞游走受体抗体
规格：1mg/1ml
英文名： CD168/HMMR
别名： CD168; CD168 antigen; HMMR; HMMR_HUMAN; Hyaluronan mediated motility receptor; Hyaluronan-mediated motility receptor (RHAMM); IHABP; Intracellular hyaluronic acid-binding protein; Intracellular hyalur
分子量： 84kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CD168/HM
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
透明质酸介导细胞游走受体抗体产品介绍：background: Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan that regulates cell adhesion and migration. HA effects are mediated through two receptors, CD44 (also designated HCAM) and the receptor of hyaluronic acid mediated motility (RHAMM). RHAMM, also designated intracellular hyaluronic acid binding protein (IHABP) and CD168, is a matrix receptor, which is linked to the plasma membrane by a GPI anchor and regulates cell motility. RHAMM expression is upregulated in malignant lymphoid tissues and is subsequently implicated in tumor progression and metastasis formation, as well as signal transduction. Although still unclear, RHAMM is thought to exist as several isoforms ranging in size. A variant isoform, designated v4, is a protein that when over-expressed, is thought to be透明质酸介导细胞游走受体抗体 the cause of transformation and metastasis formation in fibroblasts. Function: Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. Subcellular Location: Cell surface. Cytoplasm. Tissue 透明质酸介导细胞游走受体抗体Specificity: Expressed in breast cancer cell lines and in normal breast tissue. Gene ID: 3161 Database links: Entrez Gene: 3161 Human Omim: 600936 Human SwissProt: O75330 Human Unigene: 728200 Human Unigene: 740467 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
透明质酸介导细胞游走受体抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 干细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid