IQSEC3蛋白抗体
规格：1mg/1ml
英文名： IQSEC3
别名： IQ motif and Sec7 domain 3; IQ motif and SEC7 domain-containing protein 3; IQEC3_HUMAN; Iqsec3; KIAA1110; MGC30156.
分子量： 127kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IQSEC3
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆
IQSEC3蛋白抗体产品介绍：background: IQSEC3 (IQ motif and SEC7 domain-containing protein 3), also known as KIAA1110, is a 1,182 amino acid protein that belongs to the BRAG family. Localizing to the cytoplasm, IQSEC3 is expressed predominantly in ***** brain, where it is observed predominantly in the cerebral cortex and olfactory bulb, with no expression found in the fetal brain. IQSEC3 contains an IQ domain, a PH domain and a SEC7 domain, and interacts with SAP 97 and PSD-95. Acting as a guanine nucleotide exchange factor (GEF) for ARF1, IQSEC3 is encoded by a gene that maps to human chromosome 12p13.33 and mouse chromosome 6 F1. Mutations to the gene encoding IQSEC2 have been linked to non-syndromic X-linked intellectual disability, while both IQSEC1 and IQSEC3 may be candidates for autosomal ID screening. IQSEC3 exists as two alternatively spliced isoforms. Function: Acts as a guanine nucleotide exchange factor (GEF) for ARF1. Subunit: Interacts with IQSEC3蛋白抗体DLG1 and DLG4. {ECO:0000250}. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed specifically in the ***** brain, predominantly in the cerebral cortex and the olfactory bulb, but not in the fetal brain. Expressed only in mature neurons, but not in undifferentiated neural stem precursor cells (NSPCs), nor in glioma cells. Similarity: Belongs to the BRAG family. Contains 1 IQ domain. Contains 1 PH domain. IQSEC3蛋白抗体Contains 1 SEC7 domain. Gene ID: 440073 Database links: Entrez Gene: 440073 Human SwissProt: Q9UPP2 Human Unigene: 536319 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
IQSEC3蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid