钾离子通道亚家族T成员1抗体
规格：1mg/1ml
英文名： KCNT1
别名： bA100C15.2; EIEE14; ENFL5; KCa4.1; KCNT1; KCNT1_HUMAN; Potassium channel subfamily T member 1; Potassium channel, subfamily T, member 1; SLACK.
分子量： 137kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KCNT1
交叉反应：Human,
细胞定位：细胞膜
钾离子通道亚家族T成员1抗体产品介绍：background: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] Function: Outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro). Subcellular Location: Cell membrane. 钾离子通道亚家族T成员1抗体Tissue Specificity: Highest expression in liver, brain and spinal cord. Lowest expression in skeletal muscle. Post-translational modifications: Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity. Similarity: Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily. Contains 1 RCK N-terminal domain. 钾离子通道亚家族T成员1抗体Gene ID: 57582 Database links: Entrez Gene: 57582 Human Entrez Gene: 227632 Mouse Entrez Gene: 60444 Rat Omim: 608167 Human SwissProt: Q5JUK3 Human SwissProt: Q6ZPR4 Mouse SwissProt: Q9Z258 Rat Unigene: 104950 Human Unigene: 119462 Mouse Unigene: 162642 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钾离子通道亚家族T成员1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 神经生物学 通道蛋白 细胞膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid