纤维蛋白肽B/血纤肽B抗体
规格：1mg/1ml
英文名： Fibrinopeptide B
别名： FGB; FIBB_HUMAN; Fibrinopeptide B.
分子量： 1.5kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Fibrinop
交叉反应：Human,
细胞定位：分泌型蛋白
纤维蛋白肽B/血纤肽B抗体产品介绍：background: The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]. Function: Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Subunit: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain. Subcellular Location: Secreted. Post-translational modifications: The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. 纤维蛋白肽B/血纤肽B抗体DISEASE: Defects in FGB are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding. Similarity: Contains 1 fibrinogen C-terminal domain. Gene ID: 2244 纤维蛋白肽B/血纤肽B抗体Database links: Entrez Gene: 2244 Human Entrez Gene: 110135 Mouse Entrez Gene: 24366 Rat Omim: 134830 Human SwissProt: P02675 Human SwissProt: Q8K0E8 Mouse SwissProt: P14480 Rat Unigene: 300774 Human Unigene: 30063 Mouse Unigene: 11416 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
纤维蛋白肽B/血纤肽B抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid