钾/钠超极化激活环核苷酸门控通道蛋白2抗体
规格：1mg/1ml
英文名： HCN2
别名： BCNG-2; BCNG2; HCN 2; Brain cyclic nucleotide gated channel 2; Brain cyclic nucleotide-gated channel 2; HAC1; Hcn2; HCN2_HUMAN; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated cha
分子量： 97kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human HCN2
交叉反应：Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,
细胞定位：细胞膜
钾/钠超极化激活环核苷酸门控通道蛋白2抗体产品介绍：background: Hyperpolarization-activated, cyclic nucleotide-binding channels (HCN) are voltage-gated cation channels that are activated by direct binding of intracellular cyclic nucleotides. The HCN family consists of four members (HCN1–4), each with a core transmembrane segment domain and a carboxy-terminal 120 amino-acid cyclic nucleotide-binding domain motif (1). HCN channels are expressed in the brain, heart, thalamus and testis (1). The pacemaker properties of HCN channels contribute to spontaneous rhythmic activity in the brain and heart (1). The genes encoding human HCN1 and HCN2 map to chromosomes 5 and 19p13.3, respectively (2,3). The genes encoding HCN3 and HCN4 map to chromosomes 1q21.3 and 15q24-q25, respectively (4,5). Function: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation钾/钠超极化激活环核苷酸门控通道蛋白2抗体 to more negative voltages. Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN1. Interacts with KCNE2. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Highly expressed throughout the brain. Detected at low levels in heart. Similarity: Belongs to the potassium channel HCN family. Contains 1 cyclic nucleotide-binding domain. Gene ID: 610 Database links: Entrez Gene: 610 Human Entrez Gene: 15166 Mouse钾/钠超极化激活环核苷酸门控通道蛋白2抗体Entrez Gene: 114244 Rat Omim: 602781 Human SwissProt: Q9UL51 Human SwissProt: O88703 Mouse SwissProt: Q9JKA9 Rat Unigene: 124161 Human Unigene: 12956 Mouse Unigene: 224995 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钾/钠超极化激活环核苷酸门控通道蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 神经生物学 信号转导 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid