富含亮氨酸胞浆蛋白CBY1抗体
规格：1mg/1ml
英文名： CBY1
别名： PGEA1; CBY1; C22orf2; CBY; Cytosolic leucine rich protein; HRIHFB2025; PIGEA 14; PIGEA-14; PKD2 interactor, Golgi and endoplasmic reticulum-associated 1; Protein Chibby.
分子量： 14kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CBY1
交叉反应：Human,
细胞定位：细胞核
富含亮氨酸胞浆蛋白CBY1抗体产品介绍：background: Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Function: TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. Subunit: Homodimer. Interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region 富含亮氨酸胞浆蛋白CBY1抗体of beta-catenin. Subcellular Location: Nucleus speckle. Golgi apparatus, trans Golgi network. Note: Nuclear, in a punctate manner. Also found in the trans Golgi. DISEASE: Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors. Similarity: Belongs to the 富含亮氨酸胞浆蛋白CBY1抗体chibby family. Gene ID: 25776 Database links: Entrez Gene: 25776 Human SwissProt: Q9Y3M2 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
富含亮氨酸胞浆蛋白CBY1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导 干细胞 转录调节因子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid