甲羟戊酸激酶抗体
规格：1mg/1ml
英文名： MVK
别名： LH receptor mRNA binding protein; LRBP; Mevalonate kinase; Mevalonic aciduria; MK antibody MVLK; KIME_MOUSE.
分子量： 42kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse MVK
交叉反应：Mouse, Rat,
细胞定位：细胞浆
甲羟戊酸激酶抗体产品介绍：background: MVK encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of MVK results in mevalonic aciduria. Function: May be a regulatory site in cholesterol biosynthetic pathway. Subunit: Homodimer. Subcellular Location: Cytoplasm. DISEASE: Defects in MVK are the cause of mevalonic aciduria (MEVA) [MIM:610377]. It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy,甲羟戊酸激酶抗体 anemia, hypotonia, myopathy, and ataxia. Defects in MVK are the cause of hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) [MIM:260920]. HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis. Concentration of IgD, and often IgA, are above normal.甲羟戊酸激酶抗体 Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily. Gene ID: 4598 Database links: Entrez Gene: 4598 Human Omim: 251170 Human SwissProt: Q03426 Human Unigene: 130607 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
甲羟戊酸激酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 转录调节因子 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid