二磷酸3核苷酸酶抗体
规格：1mg/1ml
英文名： BPNT1
别名： 4-phosphatase; Bisphosphate 3 prime nucleotidase; Bpnt1; BPNT1_HUMAN; BPntase; PAP inositol 1,4 phosphatase; PAP-inositol-1; PIP.
分子量： 33kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human BPNT1
交叉反应：Human, Mouse, Rat, Cow,
细胞定位：
二磷酸3核苷酸酶抗体产品介绍：background: BPNT1 is a member of the magnesium-dependent, lithium-sensitive phosphomonoesterase superfamily. Using magnesium as a cofactor, BPNT1 catalyzes the conversion of PAPS (adenosine 3’-phosphate 5’ phosphosulfate) to APS (adenosine 5’-phosphosulfate) and the conversion of PAP (3’(2’)-phosphoadenosine 5’ phosphate) to AMP (adenosine 5’-phosphate). Expressed ubiquitously with highest levels in brain and kidney, BPNT1 is potently inhibited by lithium, a drug used for the treatment of manic depression and bipolar affective disorder, suggesting a possible role for BPNT1 in the etiology of mood disorders. Inhibition of BPNT1 l二磷酸3核苷酸酶抗体eads to an accumulation of PAP and subsequent inhibition of sulfotransferases which may result in changes in gene expression, changes in phosphatidylinositol second messenger function and/or changes in sulfation processes. Function: Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6. Tissue Specificity: Highly expressed in kidney, liver, pancreas and heart. Detected at lower levels in brain, placenta, lung and skeletal muscle.二磷酸3核苷酸酶抗体 Similarity: Belongs to the inositol monophosphatase family. Gene ID: 10380 Database links: Entrez Gene: 10380 Human Omim: 604053 Human SwissProt: O95861 Human Unigene: 406134 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
二磷酸3核苷酸酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid