谷氨酸受体相互作用蛋白2抗体
规格：1mg/1ml
英文名： GRIP2
别名： Glutamate receptor-interacting protein 2; GRIP-2; GRIP2_HUMAN; GRIP2; KIAA1719.
分子量： 112kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GRIP2
交叉反应：Human,
谷氨酸受体相互作用蛋白2抗体细胞定位：细胞浆 细胞膜
产品介绍：background: GRIP2 are involved in the targeting of GluR-2 and GluR-3 to the synapse. GRIP1 and GRIP2 are widely expressed in brain, with the highest levels in the cerebral cortex, hippocampus and olfactory bulb. They are both enriched in synaptic plasma and postsynaptic density fractions. GRIP1 is expressed in early development before the expression of AMPA receptors, specifically postnatal days 8-10, while GRIP2 expression parallels that of AMPA receptors during later developmental stages. GRIP1 and GRIP2 may mediate the endocytotic rate of GluR-2 and GluR-3 in response to the phosphorylation of the receptors on Ser 880 by PKC, which is implicated in the induction of cerebellar long-term depression (LTD). Function: May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator 谷氨酸受体相互作用蛋白2抗体of the trafficking of its binding partners at specific subcellular location in neurons. Subunit: Interacts with EFNB1, EFNB3, GRIA2, GRIA3, CSPG4 and GRIPAP1. Can form homomultimers and heteromultimers with GRIP1 (By similarity). Interacts with the C-terminal tail of PRLHR. Subcellular Location: Cytoplasm. Membrane; Peripheral membrane protein. Similarity: Belongs to the GRIP2 family. Contains 谷氨酸受体相互作用蛋白2抗体7 PDZ (DHR) domains. Gene ID: 80852 Database links: Entrez Gene: 80852 Human Entrez Gene: 509537 Cow Entrez Gene: 484638 Dog Entrez Gene: 243547 Mouse Entrez Gene: 171571 Rat SwissProt: Q9C0E4 Human SwissProt: Q9WTW1 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
谷氨酸受体相互作用蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid