人**瘤病毒18型E4抗体
规格：1mg/1ml
英文名： HPV18 E4
别名： HPV18 E4 protein; HPV 18 E4 protein; Human Papilloma Virus; Human papillomavirus type 18 E4; Human papillomavirus type 18 E4; Protein E4; Human Papillomavirus 18 (E4); HPV18 E4; E4 protein (HPV18); VE
分子量： 10kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from HPV18 E4 prote
交叉反应：HPV18
细胞定位：细胞核
人**瘤病毒18型E4抗体产品介绍：background: The two primary oncoproteins of high risk HPV types are E6 and E7. The “E” designation indicates that these two proteins are expressed early in the HPV life cycle, while the "L" designation indicates late expression. The HPV genome is composed of six early (E1, E2, E4, E5, E6, and E7) ORFs, two late (L1 and L2) ORFs, and a non-coding long control region (LCR). After the host cell is infected viral early promoter is activated and a polycistronic primary RNA containing all six early ORFs is transcribed. This polycistronic RNA then undergoes active RNA splicing to generate multiple isoforms of mRNAs. One of the spliced isoform RNAs, E6*I, serves as an E7 人**瘤病毒18型E4抗体mRNA to translate E7 protein. However, viral early transcription subjects to viral E2 regulation and high E2 levels repress the transcription. HPV genomes integrate into host genome by disruption of E2 ORF, preventing E2 repression on E6 and E7. Thus, viral genome integration into host DNA genome increases E6 and E7 expression to promote cellular proliferation and the chance of malignancy.人**瘤病毒18型E4抗体 The degree to which E6 and E7 are expressed is correlated with the type of cervical lesion that can ultimately develop. Similarity: Belongs to the papillomaviridae E4 protein family. Gene ID: 1489086 Database links: UniProtKB: locus VE4_HPV18, accession P06791 GeneID:1489086 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
人**瘤病毒18型E4抗体产品应用：IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid