钠通道亚基β4抗体
规格：1mg/1ml
英文名： SCN4B
别名： SCN4B_MOUSE; SCN4B_HUMAN; Sodium channel subunit beta-4.
分子量： 22kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SCN4B
交叉反应：Mouse, Rat,
细胞定位：细胞膜
钠通道亚基β4抗体产品介绍：background: The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009] Function: Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Subunit: The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds. Associates with SCN2A. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed at a high level in dorsal root ganglia, at a钠通道亚基β4抗体 lower level in brain, spinal cord, skeletal muscle and heart. Post-translational modifications: Contains a number of interchain disulfide bonds with SCN2A. DISEASE: Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. Similarity: Belongs to the钠通道亚基β4抗体 sodium channel auxiliary subunit SCN4B (TC 8.A.17) family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Gene ID: 399548 Database links: Entrez Gene: 6330 Human Entrez Gene: 399548 Mouse SwissProt: Q8IWT1 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钠通道亚基β4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 神经生物学 信号转导 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid