细胞表面趋化因子受体4相关蛋白4抗体
规格：1mg/1ml
英文名： CNOT4
别名： CCR4 NOT transcription complex subunit 4; CCR4-associated factor 4; CCR4-NOT transcription complex subunit 4; CLONE243; CNOT 4; Cnot4; CNOT4_HUMAN; E3 ubiquitin-protein ligase CNOT4; NOT 4; NOT4 (nega
分子量： 64kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CNOT4
交叉反应：Human, Mouse, Rat, Pig, Horse, Rabbit,
细胞定位：细胞核 细胞浆 分泌型蛋白
细胞表面趋化因子受体4相关蛋白4抗体产品介绍：background: The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription as well as mRNA degradation. Various subunits within the complex are involved in influencing nuclear hormone receptor activities. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome. CNOT4 (CCR4-NOT transcription complex subunit 4), also known as CCR4-associated factor 4 and E3 ubiquitin-protein ligase CNOT4, is a 575 amino acid protein that is a subunit of the CCR4-NOT complex. CNOT4 contains one C3H1-type zinc finger, one RING-type zinc finger and one RRM (RNA recognition motif) domain. Via its RING domain, CNOT4 binds E2 ubiquitin ligases. CNOT4 functions as a UbcH5B-dependent ubiquitin-protein ligase (E3 ligase). There are eight isoforms of CNOT4 that are expressed as a result 细胞表面趋化因子受体4相关蛋白4抗体of alternative splicing events. Function: Has E3 ubiquitin ligase activity. The CCR4-NOT complex functions as general transcription regulation complex. Subunit: Subunit of the CCR4-NOT core complex that contains CHAF1A, CHAF1B, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6 and CNOT8. Binds CNOT1 via its C-terminus. Binds E2 ubiquitin ligases via its RING domain. Interacts (via RING domain) with UBE2D2. Subcellular Location: Cytoplasm. Nucleus. Post-translational modifications: Autoubiquitinated. Similarity: Contains 1 C3H1-type zinc finger. Contains 1 RING-type zinc finger. Contains 1 RRM (RNA recognition motif) domain. Gene ID: 4850 Database links: Entrez Gene: 4850 Human细胞表面趋化因子受体4相关蛋白4抗体 Entrez Gene: 53621 Mouse Entrez Gene: 312227 Rat Entrez Gene: 380304 Xenopus laevis Omim: 604911 Human SwissProt: O95628 Human SwissProt: Q8BT14 Mouse Unigene: 490224 Human Unigene: 214525 Mouse Unigene: 398182 Mouse Unigene: 203387 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞表面趋化因子受体4相关蛋白4抗体产品应用：WB=1:100-500 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 通道蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid