丝氨酸/苏氨酸蛋白激酶37抗体
规格：1mg/1ml
英文名： PASK/STK37
别名： DKFZP434O051; DKFZp686P2031; hPASK; KIAA0135; MGC93882; mKIAA0135; PAS domain containing serine/threonine kinase; PAS domain containing serine/threonine protein kinase; PAS domain-containing serine/th
分子量： 143kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PASK/STK
交叉反应：Human, Mouse, Rat, Horse,
细胞定位：细胞核 细胞浆
丝氨酸/苏氨酸蛋白激酶37抗体产品介绍：background: This gene encodes a member of the serine/threonine kinase family that contains two PAS domains. Expression of this gene is regulated by glucose, and the encoded protein plays a role in the regulation of insulin gene expression. Downregulation of this gene may play a role in type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] Function: Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of 丝氨酸/苏氨酸蛋白激酶37抗体glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation. Subcellular Location: Cytoplasm. Tissue Specificity: Ubiquitously expressed, with slightly higher expression in brain, prostate and testis. Reduced expression was found in placenta. Post-translational modifications: Autophosphorylated on Thr-1161 and Thr-1165. Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Contains 2 PAS (PER-ARNT-SIM) domains. Contains 1 protein kinase domain. Gene ID: 23178 Database links丝氨酸/苏氨酸蛋白激酶37抗体: Entrez Gene: 23178 Human Entrez Gene: 269224 Mouse Omim: 607505 Human SwissProt: Q96RG2 Human SwissProt: Q8CEE6 Mouse Unigene: 397891 Human Unigene: 379454 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
丝氨酸/苏氨酸蛋白激酶37抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid