小细胞蛋白PARVβ抗体
规格：1mg/1ml
英文名： PARVB
别名： Affixin; Beta parvin; Beta-parvin; CGI 56; CGI-56; Parvb; PARVB_HUMAN; parvin, beta.
分子量： 42kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PARVB
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆 细胞膜
小细胞蛋白PARVβ抗体产品介绍：background: This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011] Function: Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion,小细胞蛋白PARVβ抗体 cell spreading, establishment or maintenance of cell polarity, and cell migration. Subunit: Interacts with DYSF. Interacts with ILK, ARHGEF6, PXN (via LD motifs), ACTN2 and actin. Subcellular Location: Cell junction > focal adhesion. Cell membrane. Cytoplasm > cytoskeleton. Constituent of focal adhesions. Tissue Specificity: Expressed predominantly in heart and skeletal muscle. Similarity: Belongs to 小细胞蛋白PARVβ抗体the parvin family. Contains 2 CH (calponin-homology) domains. Gene ID: 29780 Database links: Entrez Gene: 29780 Human Entrez Gene: 170736 Mouse Entrez Gene: 362973 Rat Omim: 608121 Human SwissProt: Q9HBI1 Human SwissProt: Q9ES46 Mouse Unigene: 475074 Human Unigene: 323892 Mouse Unigene: 16709 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
小细胞蛋白PARVβ抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid