G蛋白信号转导调节因子1抗体
规格：1mg/1ml
英文名： RGS1
别名： 1R20; B cell activation protein BL34; B-cell activation protein BL34; BL34; Early response protein 1R20; IER 1; IER1; Immediate early response 1 B cell specific; immediate-early response 1, B-cell spe
分子量： 24kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RGS1
交叉反应：Human, Mouse, Rat, Cow, Horse,
细胞定位：细胞核
G蛋白信号转导调节因子1抗体产品介绍：background: This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008] Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may G蛋白信号转导调节因子1抗体be involved in the regulation of B-cell activation and proliferation. Tissue Specificity: B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high. Post-translational modifications: Could be phosphorylated. Might be functionally regulated by protein kinase(s). Similarity: Contains 1 RGS domain. Gene ID: 5996 Database links: Entrez Gene: 100034151 Horse Entrez Gene: 5996 Human Entrez G蛋白信号转导调节因子1抗体Gene: 50778 Mouse Entrez Gene: 54289 Rat Omim: 600323 Human SwissProt: Q6RG78 Horse SwissProt: Q08116 Human SwissProt: Q9JL25 Mouse SwissProt: P97844 Rat Unigene: 75256 Human Unigene: 103701 Mouse Unigene: 14787 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
G蛋白信号转导调节因子1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 **细胞 b-**细胞 G蛋白信号
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid