溶质载体家族蛋白16成员A11抗体
规格：1mg/1ml
英文名： SLC16A11
别名： FLJ90193; MCT 11; Monocarboxylate transporter 11; MOT11_HUMAN; SLC16A11; Solute carrier family 16 member 11 (monocarboxylic acid transporter 11); Solute carrier family 16 member 11.
分子量： 48kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SLC16A11
交叉反应：Human,
细胞定位：细胞膜
产品介绍：Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates. 溶质载体家族蛋白16成员A11抗体Subcellular Location: Cell membrane. Tissue Specificity: Expressed in liver, salivary gland and thyroid. DISEASE: Disease susceptibility is associated with variations affecting the gene represented in this entry. Variants Ile-113, Gly-127, Ser-340 and Thr-443 are individually associated with a 20% increased risk of NIDDM. These variants are present at 50% frequency in Native-American samples, 10% in east Asian, while they are rare in European and African samples populations. These haplotypes probably derive from H.sapiens neanderthalensis (Neanderthal) introgression (PubMed:24390345). Disease description:A multifactorial disorder of glucose homeostasis 溶质载体家族蛋白16成员A11抗体caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Similarity: Belongs to the major facilitator superfamily. 溶质载体家族蛋白16成员A11抗体Monocarboxylate porter (TC 2.A.1.13) family. Gene ID: 162515 Database links: Entrez Gene: 162515 Human Entrez Gene: 216867 Mouse Entrez Gene: 287450 Rat Omim: 615765 Human SwissProt: Q8NCK7 Human SwissProt: Q5NC32 Mouse Unigene: 336564 Human Unigene: 289238 Mouse Unigene: 89414 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品应用：溶质载体家族蛋白16成员A11抗体WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 糖尿病 ***病
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid